CJC-1295 (No DAC) is a synthetic 29-amino acid peptide analog of Growth Hormone Releasing Hormone (GHRH) used to study pulsatile growth hormone secretion. It serves as a selective tool for investigating the stimulation of the pituitary gland without the extended half-life associated with Drug Affinity Complex (DAC) modifications. For research use only.
CJC-1295 (No DAC) is a tetrasubstituted peptide sequence designed to explore the biochemical regulation of the human growth hormone (hGH) axis. By substituting four specific amino acids in the original GRF 1-29 sequence, this peptide exhibits enhanced resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), allowing for a longer duration of action compared to native GHRH while still preserving a short biological half-life (~30 minutes). This reagent is specifically synthesized to allow researchers to observe the activation of GHRH receptors in the anterior pituitary. Because it lacks the DAC modification, it does not bind to serum albumin, making it an ideal model for studying discrete, controlled bursts of hormone release. Supplied as a highly stable, lyophilized powder, it is intended strictly for laboratory research; it is not for human administration.
